On September 17, 2018, the MOAND Board voted to shift from a district model to a regional model. The four-region structure consists of: Northwest, Northeast, Southwest, and Southeast regions.

Northeast Region

Counties:

Scotland, Clark, Knox, Lewis, Shelby, Marion, Monroe, Ralls, Pike, Audrain, Lincoln, Montgomery, Jefferson, Franklin, Osage, Calloway, Warren, Gasconade, St Louis, St Charles

Southeast Region

Counties:

Bollinger, Butler, Cape Girardeau, Carter, Crawford, Dent, Dunklin, Howell, Iron, Madison, Maries, Mississippi, New Madrid, Oregon, Pemiscot, Perry, Phelps, Reynolds, Ripley, Saint Francois, Scott, Shannon, Ste. Genevieve, Stoddard, Texas, Washington, Wayne.

Northwest Region

Counties:

Adair, Andrew, Atchison, Bates, Benton, Boone, Buchanan, Caldwell, Carroll, Cass, Chariton, Clay, Clinton, Cole, Cooper, Daviess, DeKalb, Gentry, Grundy, Harrison, Henry, Holt, Howard, Jackson, Johnson, Lafayette, Linn, Livingston, Macon, Mercer, Miller, Moniteau, Morgan, Nodaway, Pettis, Platte, Putnam, Randolph, Ray, Saline, Schuyler, Sullivan, Worth

Southwest Region

Counties: Vernon, Saint Clair, Hickory, Camden, Pulaski, Barton, Cedar, Polk, Dallas, Laclede, Jasper, Dade, Greene, Webster, Wright, Newton, Lawrence, Christian, Douglas, McDonald, Barry, Stone, Taney, Ozark

Saint Louis District